Brandy (voiced by Kaley Cuoco) is one of the main characters in Brandy & Mr. Whiskers. She's a anthropomorphic dog who came to live in the Amazon Jungle with Mr. Whiskers. She tends to be mean and can be such a drama queen, but she is good-hearted at times.
- Brandy will appear in Jeffrey & Friends vs. Godzilla and Jeffrey & Friends vs. Jaws.
- Brandy will guest star in Jeffrey & Friends meet Jimmy Neutron: Boy Genius. At the end, she'll join the team with Mr. Whiskers, Sam and Max.