Cruella DeVil (currently voiced by Susanne Blakeslee) is the main antagonist in Jaden's Adventures of 101 Dalmatians. She swore revenge on Roger and Anita after they refused to sell her the puppies. Her two henchmen, Jasper and Horace, kidnapped Jaden, Berkeley Beetle and the puppies. Jaden's friends helped Pongo and Perdita rescue Jaden, Berkeley and the puppies, whereupon Cruella pursued them until she wrecked her car.
- Cruella will become Jeffrey's enemy in Jeffrey and Friends' Adventures of 101 Dalmatians and Jeffrey and Friends' Adventures of 101 Dalmatians II: Patch's London Adventure.
- Cruella will return for revenge in Jeffrey & Friends meet The Rescuers.
- Cruella will return in the Jeffrey & Friends' Adventures Chronicles episode, The day Patch falls in love.
- Cruella will appear again in Xion's Ohana Adventures of 102 Dalmatians.
- Cruella will become Aaron's enemy in Aaron's Adventures in 101 Dalmatians.
- Cruella will return for revenge in Aaron's Adventures in 101 Dalmatians 2: Patch's London Adventure
- In the 2015 movie Descendants ,Cruella will have a Son named Carlos (pertrayed by Cameron Boyce).
- FUN FACT: Cruella was originally planned to appear as the main villain for The Rescuers. But the idea was dropped since Disney wasn't planning to do sequels at the time.