The Indominus Rex is the main antagonist of Jurassic World.
- The Indominus Rex becomes Jeffrey, Jaden, Hiccup and Juniper Lee's enemy in Jeffrey, Jaden, Hiccup and Juniper Lee go to Jurassic World.
- Indominus Rex will become Twilight and Kyle's enemy in Twilight and Kyle goes to Jurassic World.
- Indominus Rex will be revived by Chase Young, and joined the Heylin Empire for revenge in Twilight and Kyle's Adventures of Equestria Girls: Friendship Games.
- Twilight and her friends have always hated Indominus Rex so much for murdering people, so Twilight allows her Godzilla to fight the brutal dinosaur.