Jesse went to Duel Academy as a transfer student, and became quick friends with Jaden. He helped Jaden take down Pr. Viper, who had start survival duels, which were harming the duelists. After Jaden dueled Viper, they were sent to a world by Yubel were Duel Monster spirits were alive. In order to get everyone back home, Jesse stayed behind to finish dueling Yubel, and Jaden was determinded to get him back. Jaden and his friends went back to that world, only to find it completely different than the one they were at. After a long time searching, they found Jesse, but he was possessed by Yubel. Jaden freed him. But Jaden had to defeat Yubel in order to get everyone home. After Jaden combined his sould with Yubel's, Jesse and everyone else were sent back home.
After a long series of adventures, Jaden and his friends reuinte with Jesse, who was his old self from before. Jesse was invited to go on their adventures, and he (along with his Crystal Beast monsters) happily accepted.
- Jesse's main Duel Monster spirit partner is Ruby Carbuncle.
- Jesse is one of the famous Three J's.
- Jesse joins the team at the beginning of Jaden's Adventures Season 2, which start with Jaden Learns How to Train Your Dragon.
- Jesse becomes close friends with Rarity because of their interest in gems.
- Jesse will be Xion's godfather.
- Jesse will be one of the hosts in Jeffrey, Jaden, Pooh & Friends' Storm Adventures of Muppets Tonight.
- In Jeffrey, Jaden & Friends' Storm Adventures of Star Fox Adventures, Jesse will meet May and fall in love with her. At the end, the two start a relationship with each other.
- Jesse becomes the main protagonist in Jesse, Xion, and Luigi's Mansion.
- In Jeffrey, Jaden, & Friends' Storm Adventures of Pokemon: Destiny Deoxys, Jesse will believe that another Pokemon trainer named Sid is trying to take May from him, and will feel heartbroken during the Adventure.
- Jesse will finally propose to May in Jeffrey, Jaden, & Friends' Storm Adventures of Rio 2.
- Jesse will finally marry May in Rainbow Bond.
- Upon becoming the New King of Games, Jaden appoints Jesse as his royal vizier.
- Jesse might become a Keyblade wielder someday. When and how is currently unknown.
- In Jaden's Adventures of Toy Story 3, it's revealed that Jesse is the cousin of Bonnie Anderson.
- In Japan, Jesse is known, as Johan Anderson.