"Behold My Powers. I am the strongest Pokemon in the world. Stronger even than Mew!" - Mewtwo
Mewtwo (voiced by Phillip Bartlett) is the main antagonist of Jaden's Adventures of Pokemon the First Movie, but is a misunderstood character. He was created by humans to be a slave, but with his psychic powers, planned to rule the world instead. Jaden was disgusted with what he was thinking, on how humans are a disgrace. Mewtwo stole Ash, and a whole group of other trainers Pokemon to make clones with their DNA. By the end of the movie, Mewtwo experiences a change of heart and stops his destructive rampage; thanks to Ash Ketchum. Wanting to find himself, Mewtwo erased the memories of those present (including Jaden).
- Mewtwo goes on several adventures with Winnie the Pooh.
- Jeffrey and his friends will face Mewtwo in Jeffrey & Friends' Adventures of Pokemon the First Movie. Near the end, Mewtwo will erase the memories of Ash and the other trainers that came to his island. But he won't erase the memories of Jeffrey and his team. However, he does make them promise that they'll never tell anyone of the existence of him and the clone Pokemon.
- Mewtwo is also an adopted father to a forest fairy, her name is Aisling.