Mr. Whiskers (voiced by Charlie Adler) is a white lopped eared rabbit. While he is a silly, smelly, sloppy, gross, clumsy, clueless, selfish, short-tempered, arrogant, cranky, naughty, hyperactive and annoying pest, he is also very loving, caring and intelligent with a fairly large vocabulary, which is exhibited at special moments.
- Mr. Whiskers will appear in Jeffrey & Friends vs. Godzilla and Jeffrey & Friends vs. Jaws.
- Mr. Whiskers will guest star in Jeffrey & Friends meet Jimmy Neutron: Boy Genius. At the end, he'll join the team.