"You want osmosis? You've got osmosis!" -Osmosis Jones
Osmosis Jones (voiced by Chris Rock) is a white blood-cell cop who lived in the City of Frank (which is inside a man's body) and the main protagonist of Jaden meets Osmosis Jones. He's funny, adventure-seeking, rebellious and has little respect for authority. Since he was discredited, he got suspended for unnecessary force and placed in the out-of-the-way patrols. Therefore, he seizes any opportunity to be able to make a difference. But he still helps seek justice any way he can. His best friend is a red and yellow cold pill named Drix.
- Osmosis Jones will guest star in Jaden gets Hoodwinked!
- Osmosis Jones will meet Jeffrey and his team in Jeffrey & Friends meet Osmosis Jones.
- He'll reunite with them in Jeffrey & Friends' Storm Adventures with Ozzy & Drix. At the end of the series, he and Drix will join the team.