Sam (voiced by Harvey Atkin) and Max (voiced by Robert Tinker) are the main characters of the Sam & Max franchise. Sam is a 6-foot anthropomorphic dog in detective's clothing and Max is a "hyperkinetic rabbity thing". They call themselves the Freelance Police.
- Sam and Max, along with Brandy and Mr. Whiskers, will appear in Jeffrey & Friends vs. Godzilla.
- They'll appear again in Jeffrey & Friends vs. Jaws.
- They'll guest star in Jeffrey & Friends meet Jimmy Neutron: Boy Genius. At the end, they'll join the team.
- Sam, Max, Brandy and Mr. Whiskers are part of the Shell Louge Squad and Team C.A.T. Sam and Max are also part of Team Adventure, even though Brandy and Mr. Whiskers aren't.
- Sam and Max are old friends with Nails the Spider.