Stuart Little (voiced by Micheal J. Fox) is the main character of the Stuart Little francise. He's a little mouse who is adopted by the Little family. He makes friends with Margalo the bird, Snowbell the cat and Monty the alley cat.
- Stuart Little will meet Jeffrey and his team in Jeffrey & Friends meet Stuart Little.
- He'll reunite with them in Jeffrey & Friends' Adventures of Stuart Little 2. At the end, he'll join the team with Margalo, Snowbell and Monty.