Susan Murphy (or Ginormica) (voiced by Reese Witherspoon) is a young woman who became a giant woman by a meteor in Monsters vs. Aliens.
- Jeffrey will meet Susan in Jeffrey & Friends' Adventures of Monsters vs. Aliens. It's revealed that she is Jeffrey's cousin.
- Susan will attend Jeffrey and Aqua's wedding in Key of Flaming Union.
- Susan will guest star in Jeffrey, Jaden & Friends' Storm Adventures of Stitch!: The Movie.
- susan has become like a mother figure to Kyle.