"It is I, the Cham-ah-lee-on! Oh, drat! I mean the Chameleon!" -Chameleon
The Chameleon (voiced by Daran Norris) is a villain on T.U.F.F. Puppy, and serves as Set's evil right-hand man. He has a transformation suit that allows him to change himself into anything. Set promised him that he will destroy T.U.F.F. headquarters if The Chameleon helps him destroy Jaden and his friends.
- The Chameleon will make his debut in Jaden's Adventures of Fantasmic! as one of the many villain who try to destroy Jaden and Mickey Mouse.
- The Chameleon will become Jeffrey's enemy in Jeffrey, Jaden & Friends meet TRON.
- The Chameleon will return for revenge on Jaden, Jeffrey and their friends in the Jeffrey, Jaden & Friends meet Indiana Jones saga.
- In Jeffrey, Jaden and Scooby Doo on Zombie Island, The Chameleon will actually be beaten by Xion.
- Running gag: Before the Chameleon gets arrested, Jeffrey or Aqua punches him and knocks out a tooth. This is similar to Master Little in "The King and I."
- In Key of Flaming Union, Aqua punches the Chameleon harder than Jeffrey can.
- The Chameleon is cousins with Randall Boggs.
- It is rumored that Chameleon might start a relationship with Queen Chrysalis.
- He will also appeared in the epic 3 part episode of Hiccup's Adventures Chronicles, How the Chameleon Strikes Back.
- In Twilight's Adventures Chronicles, his appearance is Stealth of Chameleon, where he gets revenge on Dudley Puppy and Kitty Katswell, and tries to make Twilight, Kyle, the Rainbooms and Team Owl guilty for being threat against the Mayor and the town.