Yzma (voiced by the late Eartha Kitt) is the main antagonist in The Emperor's New Groove and the entire franchise. She is Emperor Kuzco's arch-enemy and goes out of her way to destroy him every chance she gets. She used to be Kuzco's advisor, but she kept running the country in his absence, prompting him to casually and cruelly fire her. According to Kuzco, she is "scary beyond all reason", which may not be far from the truth.
- Yzma will become Jeffrey's enemy in Jeffrey & Friends' Adventures of The Emperor's New Groove.